The second edition of hepatotoxicity the adverse effects of drugs and other chemicals on the liver will undoubtedly be useful to clinicians and scientists from many disciplines there is much for the hepatologist gastroenterologist pathologist and pharmacologist. Common side effects include phlebitis and the histamine like reaction marked by rash urticaria flushing bronchospam hypotension and facial swelling hepatotoxicity transient elevations in liver enzymes have occurred in 2 to 15 of patients treated with the echinocandins typically returning to baseline after withdrawal of therapy. Hepatotoxicity the adverse effects of drugs and other chemicals on the liver 2nd ed philadelphia lippincott 1999 pp 493 8 expert review of hepatotoxicity published in 1999 mentions that there have been at least 6 reports of acute symptomatic hepatic injury and one case of chronic hepatitis attributed to fluoxetine. Written by the foremost authority in the field this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity dr zimmerman examines the interface between chemicals and the liver the latest research in experimental hepatotoxicology the hepatotoxic risks of household industrial and environmental chemicals and the adverse effects of drugs on the liver. The idiosyncratic nature and poor prognosis of drug induced liver injury dili make this type of reaction a major safety issue during drug development as well as the most common cause for the withdrawal of drugs from the pharmaceutical market the key to predicting and preventing dili is understanding the underlying mechanisms
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